South Dakota State (6-11, 1-5) started slow and made only five of 26 field goals in the first half, as IUPUI took a 34-15 lead into halftime.
The Jackrabbits rallied to shoot 50 percent in the second half on 12 of 24 field goals, but the Jaguars shot 43 percent for the game and made 7 of 17 3-pointers.
IUPUI also sank 17 of 20 free throws.
On Thursday, IUPUI beat North Dakota State 60-46.
Hill ended the game four points shy of tenth place on IUPUI's all-time scoring list. He has 1,244 points.