WVU finished with its best shooting game of the season in league play by hitting 53.7 percent from the floor, including 11 threes.
Seton Hall never got closer than 19, and fell behind by as much as 30 twice with just minutes to play in losing for the fifth straight time, its longest losing streak in six seasons.
West Virginia's (18-7, 7-5) ball movement and passing befuddled the Pirates, who appeared flustered and uncomfortable against the motion sets. Seton Hall (15-11, 5-8) never settled, and was forced to rely on Jeremy Hazell's outside shooting for the majority of its scoring.
The freshman had 20 points at the break and finished with a career high of 30. Brian Laing added 21 points for Seton Hall, with 19 of those in the second half.