Willie Reed also was in double figures for Saint Louis (4-4) with 10 points. After dropping three straight away from home, the Billikens have won the first two games of a four-game home stand.
Saint Louis used 3-pointers, including 4-of-5 from Liddell, to jump out to an early 17-point lead.
Samford was 1-of-9 from 3-point range in the first 20 minutes but still trimmed the lead to 32-23 at halftime.
Saint Louis opened the second half with a 13-2 run to stretch the lead to 20. Brett Thompson capped that spurt with a baseline move that made it 45-25 with 15:48 to play. Samford never got closer than 14 after that.