Dion Dixon added 11 for Cincinnati (10-2), which has won four straight since losing to cross-town rival No. 14 Xavier.
Gavin Montgomery had 18 for the Golden Lions (1-9), and Ricky Parks had 12.
Cincinnati made just three of its first 10 shots but closed the half with a 35-9 run and led 43-16 at halftime.
The Bearcats are 9-1 at home, while Arkansas-Pine Bluff has started the season with 10 consecutive road games, including the past two without leading scorer Terrance Calvin, who was injured in a win over SMU on Dec. 15.