Fourteen of Shurna's points came in the second half, including four 3-pointers in the opening three minutes. Northwestern (13-7) led 37-31 at halftime.
The Wildcats sank 9-of-12 field goals after the break to open up a 60-39 lead.
Northwestern made 10 of its first 15 shots from the field, racing to a 28-18 lead. Moore scored 15 first-half points, including four 3-pointers.
Northwestern held Holston to 2-for-10 from 3-point range.