The Bears (6-15, 0-7 Ivy League), who lost their seventh game in a row, were led by Adrian Williams? 15 points.
Penn?s Brennan Votel hit a 3-point shot that broke a 21-21 tie late in the first half and ignited a 9-0 run.
Harrison Gaines then scored seven of his overall 12 points in the last 3:08 to give the Quakers (6-14, 2-3) a 39-29 lead at intermission.
Two baskets by Cameron Lewis keyed a 7-0 run early in the second half, which enabled Penn to break the game open and build leads as large as 20 points.
The Quakers? man-to-man defense held the Bears to 34 percent shooting and also forced 18 turnovers that Penn converted into 18 points.