Michael Nunnally had 10 points for the Tigers (13-6, 6-1 Big West). With a fourth straight win, Pacific remained atop the conference standings.
Pacific led by 15 points several times, the last at 49-34 following a dunk by Smith with 12:23 remaining.
UC Irvine closed to within 57-50 on a basket by Eric Wise with 1:40 to play. But Pat Eveland and Demetrece Young each hit two free throws to seal the Tigers' second win against the Anteaters in 12 days.