The Pride (1-2) blew an eight-point lead with 2:50 left in the game.
Kahlil McDonald hit consecutive 3s that pulled Western Kentucky (3-1) to 59-56. Caden Dickerson sank a 3-pointer with 35 seconds left for the Hilltoppers, then Brandon Peters made a quick steal and a layup for a 61-60 lead with 29 seconds left.
With the score 62-60, Hofstra called a timeout to set up one final chance at a tie. Shemiye McLendon's driving layup down the lane bounced off the rim as time expired.