Julius Wells chipped in 14 points, Bowles finished with 12 and Humpty Hitchens had 10 for the Dukes (3-1).
James Madison shot 54.2 percent (26 of 48), thanks in part to 34 points coming in the paint and 10 off fast breaks.
The Blue Hose (1-4), who didn't score once on a fast break, shot 39.2 percent (20 of 51) and went 9 for 24 from 3-point range (37.5 percent).
James Madison won the battle of the boards 33-23 and finished with 18 assists, compared to 12 by Presbyterian. Devon Moore had seven assists for the Dukes.