Hollis Hill added 11 points for the Islanders (3-5), who squashed an early second-half rally by St. Edward's with a 26-4 run.
Khaliq Gross scored 18 points and Remy Boswell had 12 for the Hilltoppers, a Division II team which counted this game as an exhibition.
Corpus Christi led 40-27 at halftime and scored the first four points of the second half before St. Edward's pulled to within 51-47 with 12:54 to play. Reynolds then scored five of the game's next seven points to spark the big run, and the Islanders went up 77-51 with 2:53 remaining.
Corpus Christi outrebounded St. Edward's 44-20 and shot 50.9 percent.