The Blue Demons (2-4) led by as many as 17 points late in the first half and were up 38-28 at halftime. They finished shooting 26 of 58 from the floor and 32 for 41 from the free-throw line.
Xavier Silas helped the Huskies (2-4) rally in the second half and pull within the final score on a 3-pointer in the final second. Silas, who entered the game seventh in the nation in scoring at 24.8 points per game, finished with a game-high 34 points to tie his season best.
Mike Stovall finished with 16 points for DePaul.