The Tigers (4-7) led 40-24 at halftime and extended their lead in the second thanks to 16-of-28 shooting (57.1 percent). Jackson State finished 32 of 62 from the floor overall (51.6 percent).
The Tornadoes (6-7) turned the ball over 21 times and were outrebounded 48-30.
Deangelo Spruill led Talladega off the bench with 14 points and was the only player to score in double figures.
Talladega, the defending Division I national champions of the United States Collegiate Athletic Association (USCAA), was 21 for 58 from the field (36.2 percent), including 7 of 22 from 3-point range (31.8 percent).