Kaylon Williams had 12 points, seven rebounds, seven assists and three steals for the Panthers (6-1), who led by only four at halftime before running away with the game in the second half.
Milwaukee, the defending Horizon champion, dominated inside, outscoring Loyola 34-8 in the paint and 16-2 on second-chance points. The Panthers outrebounded the Ramblers 42-20.
Milwaukee led by just three, 25-22, after a 3-pointer by Loyola's Chim Kadima two minutes into the second half. But a 21-7 run over the next 10 minutes put the Panthers in control, and the Ramblers never got within single digits the rest of the way.