Askia Booker had 13 points, and Andre Roberson and Spencer Dinwiddie scored 12 apiece for the Buffaloes (8-4), winners of three straight. Roberson added 12 rebounds, giving him his eighth double-double this season and 13th of his career.
The Buffaloes shot 55 percent (32 of 58) from the field and dominated inside, outscoring the smaller Privateers 50-6 in the paint and 24-4 on second-chance points. Colorado improved to 6-1 at home.
Rarlensee Nelson and Generra Varmall had seven points each for the Privateers (9-6), who lost their second straight after a six-game winning streak. New Orleans was held to its lowest scoring total of the season.
It was only the second meeting between the schools; New Orleans hosted Colorado last season, winning 67-65.