Mouphtaou Yarou had 14 and JayVaughn Pinkston 13 for Villanova (8-8, 1/3 Big East). The Wildcats had lost their first three conference games -- to West Virginia, Marquette and South Florida -- for the first time since joining the Big East in 1980-81.
Thursday's 74-57 loss to South Florida was especially unusual, considering that Villanova had won 51 of its last 52 at The Pavilion, its on-campus arena.
Today, though, Villanova shot 63 percent in the first half, built a 48-36 lead and cruised to its first league victory despite committing a season-high 28 turnovers.
DePaul (10-5, 1-2) entered this game with a rare Big East victory, 84-81 over Pittsburgh Thursday. The Blue Demons are 3-54 all-time in league play.
After a five-game winning streak, DePaul has dropped two of its last three.
Following a stale performance against the South Florida Bulls it its last game, Villanova came out with more energy in an early start on this day. In that loss to USF, Villanova was outrebounded 38-26, its largest deficit of the season.
But the Wildcats were aggressive from the opening tip in this one, and won for the fourth straight time over DePaul.
Villanova's lead swelled to 78-61 with 5:51 remaining and the Blue Demons never got within double figures the rest of the game. The Wildcats also outrebounded DePaul 45-23.
The Wildcats' offensive output was their highest since scoring 106 on opening night (Nov. 11) in a 36-point rout of Monmouth (N.J.).