Khalif Wyatt scored 18 points and helped the Owls (19-5, 8-2 Atlantic 10 Conference) build a 21-point lead in the first half and remain in first place in the conference.
The Owls dominated from the start in a matchup between two of the perennial powers in the Atlantic 10. The Musketeers, playing for the fourth time in five games on the road, entered only a half-game behind the Owls in the conference standings.
Rahlir Hollis-Jefferson grabbed 10 rebounds as everyone played a role for the Owls in the easy victory. Nearly 9,500 fans dressed in "I Believe" shirts for a "White Out" at the Liacouras Center.