Bucknell, who led 38-32 at halftime, opened the second half with nine unanswered to jump ahead 47-32. The Bison never looked back, holding at least a 10 point lead the rest of the way.
The Bison hold the longest conference winning streak in the nation, having won 20 straight games against Patriot League foes dating back to last season.
Rob Delaney led Lafayette (11-14, 6-4) with 22 but fouled out with 3 minutes left to play.
Muscala, Cohen, and Willman all grabbed at least seven rebounds as Bucknell won the battle of the boards 39-22.