The game got away from South Dakota late in the first half.
Esposito and Young hit a 3-pointer each to key a 12-0 IUPUI run in a 2:19 stretch. The surge gave the Jaguars a 40-23 lead with 3:17 left in the half, and the Coyotes got no closer than 14 points afterward.
IUPUI had a 31-25 rebounding edge and outscored South Dakota 44-28 in the paint.
Charlie Westbrook scored 14 points for the Coyotes.