Wright now has 147 blocks, matching Brian Cusworth's career record. Wright also had 10 points and eight rebounds as the Crimson (23-3, 9-1 Ivy League) dominated Yale (17-7, 7-3), inside to win its 27th straight home game, the second-longest streak in the nation.
Harvard outrebounded the Bulldogs 32-22 and outscored them 32-10 in the paint.
The Crimson led 9-7 midway through the first half before going on a 16-2 run to blow it open. Kyle Casey's layup gave Harvard, which was 5 of 5 during the spurt, a 23-9 advantage with 21 seconds left.
The Bulldogs who were outshot 54.3 percent (25 of 46) to 37.2 percent (16 of 43), were led by Greg Mangano with 22 points and 11 rebounds.