With a 24-19 lead, Charleston Southern outscored the Fighting Camels 22-6 in the first half to take a 21-point lead. The Buccaneers went into halftime with a 49-25 advantage after Harper's buzzer beating 3-pointer.
Charleston Southern continued its dominance in the second half, leading by as many as 33 points.
Marvelle Harris scored 14 points and grabbed a game-high eight rebounds for Campbell (10-15, 5-6), which lost its fifth straight game. Trey Freeman had 13 points and five assists, and D.J. Mason had 12 points.
Charleston Southern knocked down 11 3-pointers, and outrebounded the Fighting Camels 40-26.