The Commodores (11-15, 5-9 Southeastern Conference) made 11 of 31 shots from beyond the arc, finishing 28 for 61 from the floor (46 percent).
Vanderbilt dominated Mississippi State in most all statistical categories, including a 51-17 rebounding margin.
It was the largest margin of victory for Vanderbilt in an SEC game since a win over Kentucky in 2008. It was also the fewest points allowed by a Vanderbilt team since a win over Alabama in January of 1949.
Mississippi State (7-19, 2-12), which has lost 12 straight games, was 15-of-18 from the free throw line, but did not score a field goal until the 8:48 mark of the first half. They finished 7 for 40 from the field.
This was the second-worst loss for Mississippi State in Humphrey Coliseum history. It was also the lowest scoring output for MSU in the shot clock era.
Earlier this month, Mississippi State lost to Missouri 78-36 at home. Due to attrition, injuries and suspensions, the Bulldogs are playing with only eight active players on their roster.
Vanderbilt opened the game with a 15-2 run and led 37-17 at halftime.
Bright finished 5-of-6 from the beyond the arc and had 2 blocked shots. Odom finished 4-of-7 and had 5 rebounds.
Jalen Steele led Mississippi State with nine points on 2-of-10 shooting.