Bethune-Cookman (2-17, 0-4) has now lost 15 consecutive games.
The Eagles jumped out to an early lead and held a 16-10 advantage at the 8:12 mark of the first half. They extended that to 35-23 at the half. NCCU surged to a 51-29 advantage with 12:31 remaining in the game.
NCCU's defense stymied the Wildcats throughout, limiting them to 29.2 percent from the field in the second half.
Clemmye Owens led the Bethune-Cookman with 14 points after making 4 of 8 3-pointers. The Wildcats turned the ball over 20 times.