Williams is an NFL prospect who returned to the Sooners this season instead of entering the draft. He had been the only player on Oklahoma's offense to start every game this season.
Eric Mensik, usually a tight end, started in Williams' place on Saturday.
Oklahoma is already without three other starting offensive linemen after center Ben Habern broke his left leg in last week's loss at Texas Tech. The Sooners are also without Brody Eldridge and Jarvis Jones.