Ray Graham, Pittsburgh's leading rusher this season, started the game and rushed for 277 yards -- the second most in school history.
Lewis did not play because of an injury that apparently occurred during a 31-3 loss to Miami on Sept. 23. He did not practice during the week.
Lewis rushed for 1,799 yards as a freshman, but was held to 143 yards total his first three games. He doesn't have a 100-yard game this season after gaining at least 110 yards in each of his final eight games last season.
Information from The Associated Press was used in this report.