Neal and Worley sat out the entire third and fourth quarters after the Volunteers scored touchdowns on each of their six first-half possessions. Worley went 11 of 13 for 104 yards and threw touchdown passes to Devrin Young, Alton "Pig" Howard and Brendan Downs. Neal opened the scoring with a career-long 47-yard touchdown.
Jones was hired away from Cincinnati in December to turn around a storied program that has produced three straight losing seasons for the first time in over a century. Jones replaced Derek Dooley, who was fired after going 15-21 in three years.
He already is making an impact in the stands. Jones' debut had an announced attendance of 97,169. Tennessee drew 87,821 fans for its home opener against Georgia State last year and had an average attendance of 89,965, its lowest since 1979.
Tennessee's one-sided victory gave those fans plenty of reason for optimism, though it did come against a Football Championship Subdivision program that has lost 17 consecutive road games. Austin Peay hasn't won away from home since beating Tennessee State 26-23 on Sept. 18, 2010.
Jones' team will face much tougher tests soon enough. Five of Tennessee's first eight games are against teams ranked 10th or higher in the Top 25: No. 1 Alabama, No. 3 Oregon, No. 5 Georgia, No. 6 South Carolina and No. 10 Florida.
Neal started the scoring with his 47-yard burst on Tennessee's opening series. The senior running back shook loose of defensive end Trey Salisbury in the backfield, raced toward the left sideline and stayed upright when free safety Johnathan Shuler pushed him in the back inside the 10-yard line.
On Austin Peay's ensuing possession, senior nose tackle Daniel Hood deflected and caught an Andrew Spivey pass for his first career interception, giving Tennessee the ball at Austin Peay's 25-yard line. The turnover set up a 14-yard touchdown run up the middle on Marlin Lane's first carry of the season. Lane would add a 4-yard touchdown run in the second quarter.
Austin Peay never recovered. Tennessee outgained Austin Peay 188-15 in the first quarter and already led 21-0 by the time the Governors got a first down. Tennessee didn't punt until midway through the third quarter and didn't commit a penalty all night.
Devrin Young capped Tennessee's third drive of the game by scoring his first career touchdown on a 9-yard pass from Worley, who was falling backward as he released the ball. Worley threw touchdown passes of 11 yards to Alton "Pig" Howard and 3 yards to tight end Brendan Downs in the second quarter.
Tennessee earned its 800th victory in program history and became the eighth school in the nation to reach that plateau. The others are Michigan, Texas, Notre Dame, Nebraska, Ohio State, Oklahoma and Alabama.
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Ohio State remained No. 1 in the AP Top 25 and tied a poll record Sunday despite lagging support from voters. Meanwhile, No. 2 TCU and No. 3 Baylor edged forward and No. 4 Michigan State slipped.
Will Grier threw four touchdown passes to four receivers -- all in the first half -- and No. 25 Florida downed third-ranked Mississippi 38-10 on Saturday night.
Leonard Fournette highlighted his SEC-record third straight 200-yard game with a 75-yard touchdown run, and No. 9 LSU overcame Eastern Michigan 44-22 on Saturday night.
An officiating error led to an Oklahoma State touchdown Saturday in the Cowboys' 36-34 win over Kansas State.
Texas A&M receiver Ricky Seals-Jones, who was ejected for targeting midway in the second quarter of Saturday's game, took to Twitter late in the game, retweeting a tweet that questioned the call.
As if things weren't going bad enough at Texas, the Longhorns appear to have players on Twitter during lopsided losses and jabs at their coach accidentally being sent from other nearby teams.