EUGENE, Ore. (AP) -- There was no letdown for No. 20 Oregon when Washington came to town.
Kellen Clemens threw for 425 yards and four touchdowns and the Ducks beat the Huskies 45-21 on Saturday for their second straight decisive win over their northwest rivals.
A week after a big road win at Arizona State, a loss at home was the last thing Oregon needed.
"We don't want to live in the past, but that was a very big win at ASU, especially on the road," Clemens said. "But if we come home and lose to Washington, who cares?"
Clemens set an Autzen Stadium record by completing 36 passes -- he had no interceptions -- and the Ducks (6-1, 1-1 Pac-10) handed Washington (1-5, 0-3) its 11th consecutive league loss.
Demetrius Williams had five catches for 92 yards, including a pair of Clemens' scoring passes.
Isaiah Stanback completed 13-of-26 passes for 111 yards and a pair of touchdowns for Washington. He was intercepted once.
Washington fell 31-6 to the Ducks last year. Oregon's 45 points was the most they've scored against the Huskies since a 58-0 victory in 1973.
"It's a great rivalry, but I didn't think we lived up to our end of it," said first-year Washington coach Tyrone Willingham.
While the Huskies jumped out to an early lead on Stanback's 26-yard scoring pass to Anthony Russo, Oregon had the next three TDs.
Clemens hit Demetrius Williams with a 1-yard pass and then Jaison Williams from 8 yards out. Oregon made it 21-7 when Demetrius Williams pulled down another pass from Clemens, stumbling into the end zone for a 30-yard reception with two Washington defenders trying to pull him down.
Terrence Whitehead caught an 11-yard scoring pass from Clemens to open the second half, making it 28-7. That pass moved Clemens past Joey Harrington into third on Oregon's career list with 60 touchdown passes.
Matt Evenson added a 30-yard field goal before freshman Jonathan Stewart's 17-yard scoring run made it 38-7.
The Huskies showed some life in the fourth quarter.
Stanback found Robert Lewis with a 5-yard touchdown pass with 10:08 to go, and Ty Eriks ran in a 1-yard score some five minutes later to make it 38-21.
The Ducks responded with Brian Paysinger's 5-yard TD run in the final minutes, and Oregon finished with 570 yards in total offense.
"I believe this is a setback for our team," Stanback said. "[Oregon is] a good team. They've got guys who come to play and we didn't take care of business."
Clemens' completions broke the Autzen record of 33, shared by Fresno State's Paul Pinegar (2005) and Brigham Young's Ty Detmer (1990).
"It's special. I'm excited. But I'm not a records guy," Clemens said. "At this point we wanted to go out and get our sixth win and be bowl eligible."