AMES, Iowa (AP) -- Iowa State running back Ryan Kock rushed for a career-high 179 yards and two touchdowns and the Cyclones held Missouri on a fourth-and-goal with 21 seconds left to beat the Tigers 21-16 Saturday and send coach Dan McCarney out a winner.
The Cyclones (4-8, 1-7 Big 12) snapped a six-game losing streak behind an extraordinary effort from Kock in his final collegiate game. Kock, a fullback who moved to tailback last week in place of injured Stevie Hicks, gained more yards Saturday than he had in his first three seasons.
Down five with 3:33 left, Missouri (7-4, 3-4) converted a 4th-and-1 near midfield, then reached the Iowa State 9 two plays later as Tommy Saunders made leaping grabs of 23 and 17 yards. Daniel reached the 1 on a scramble, setting up 4th-and-goal with 26 seconds left.
Daniel reached the end zone on the next play, but the Tigers were called for holding and pushed back to the 11. Shawn Moorehead sacked Daniel to end the game.
Daniel was 29-of-44 for 310 yards for Missouri, which lost for the fourth time in five games.
Iowa State moved ahead 21-10 with touchdowns on its first two possessions of the second half. Missouri jumped offsides with the Cyclones lined up for a field goal, and Iowa State took advantage by converting on fourth down. Kock scored on a 1-yard run to give Iowa State its first second-half lead in eight Big 12 games.
The Cyclones pushed their lead to 11 on a 9-yard touchdown run by Kock. Iowa State reached the Missouri 11 with 3:40 left, but Bret Culberson missed a 28-yard field goal that would have given the Cyclones an eight-point lead.
Missouri's Tony Temple answered with a 7-yard TD run early in the fourth quarter, but the Tigers failed on a two-point conversion.
Early on, it looked as though the Tigers would run Iowa State off the field. But the Cyclones held Missouri to just 38 yards of total offense in the second quarter and cut its deficit to 10-7 by the break.
Iowa State aired a short video message from McCarney thanking Cyclones fans for their support following Missouri's first score and during halftime. Highlights from McCarney's tenure -- including Iowa State's win over Pittsburgh in the 2000 Insight Bowl and its 1998 victory over Iowa -- ran during breaks in play.
McCarney announced his resignation last week after 12 seasons. He finished his career at Iowa State with a 56-84 record.