Penn (1-3) jumped out to a 35-0 lead in the first half. Sandberg started the scoring when he capped a nine-play, 83-yard opening drive with a 4-yard TD run, and followed it up with a 13-yard score with :12 left in the half.
In between, Walker tossed a 5-yard TD pass to Jason Miran, and Michael DiMaggio ran in from 38 yards out. With just over a minute to go in the half, Walker tossed a 27-yard TD pass to Tyler Fisher that capped a six-play, 61-yard drive and put the game out of reach.
Matt Bassuener was 14-of-25 for 123 yards and second-half TD passes of 17 and 11 yards to Kyle VanFleet for the Hoyas (0-6).
DiMaggio rushed 11 times for 85 yards for Penn, which amassed 253 yards on the ground.
Arizona linebacker Scooby Wright's left knee injury is not season-ending, according to an MRI Wright had after Thursday night's opening win over UTSA, sources told ESPN's Brett McMurphy.
Syracuse starting quarterback Terrel Hunt left the Orange's season-opening 47-0 win over Rhode Island with a lower right leg injury and did not return.
The Mountain West told ESPN's Brett McMurphy that officials correctly ruled the final play that kept Colorado from getting a potential game-tying touchdown against Hawaii before time expired.
ESPN 300 running back Elijah Holyfield, the son of former heavyweight boxing champion Evander Holyfield, has decided to stay home and attend Georgia, he announced Friday.
Miami reserve linebacker Al-Quadin Muhammad has been suspended for the season opener against Bethune-Cookman on Saturday for a violation of team rules, a source confirmed to ESPN.com
All-American defensive end Shawn Oakman and safety Orion Stewart have been suspended for Baylor's season opener Friday against SMU for a violation of team rules, a school spokesman told ESPN.com.