Florida Atlantic (6-5, 5-1 Sunbelt Conference) has a chance to win the conference title if it beats Troy on Dec. 1.
FIU (0-11, 0-6) has lost 23 consecutive games, the longest current skid in major college football. A'mod Ned scored two touchdowns and Reggie Thompson also scored a touchdown for the Golden Panthers in the fourth quarter.
Smith finished 20-for-30 for 330 yards with an interception.
Florida International starting quarterback Wayne Younger (5-for-10 for 73 yards) left the game in the second quarter with a collar bone injury and did not return. Paul McCall was 23-for-35 for 181 yards and two touchdowns and one interception.
Florida Atlantic took a 7-0 lead in the first quarter on Smith's 16-yard touchdown pass to Conshario Johnson. Johnson bobbled the ball in the end zone but was able to hold on with his fingertips after he hit the ground.
Florida Atlantic scored a touchdown on each of its four possessions in the second quarter.
The Owls stretched their lead to 14-0 on Edgecomb's 9-yard touchdown run.
After the Golden Panthers kicked a 27-yard field goal, the Owls responded with a reverse that Housler ran 68 yards for a touchdown to make it 21-3. It was the longest rush in school history and Housler's first touchdown.
Smith tossed two touchdown passes in the second, a 14-yard touchdown pass to Chris Bonner and a 69-yard pass to Cortez Gent that made the score 35-3. Gent also caught a 44-yard touchdown pass in the fourth.