Brock Bolen added two touchdowns on the ground and Louisville's defense continued its dominant play as the Cardinals bounced back following a loss to rival Kentucky in the season opener.
Louisville (1-1) rolled up 451 yards of total offense and added touchdowns on defense and special teams. The Cardinals had 202 yards in the first quarter alone -- just three less than they managed in the loss to Kentucky -- and manhandled the overmatched Golden Eagles (1-1), who remained winless against teams from the Football Bowl Subdivision.
Cantwell, who looked harried and unsettled against the Wildcats, appeared considerably calmer against the Golden Eagles, a member of the Football Championship Subdivision. Showing a deft touch he lacked against Kentucky, Cantwell completed 15-of-23 passes and threw touchdowns to Troy Pascley and Pete Nochta.
Louisville wasn't perfect. The Cardinals turned the ball over twice and Cantwell got hit hard more than once. Louisville also played the second half without its two most experienced offensive linemen when center Eric Wood and left tackle George Bussey went down with minor injuries.
Still, the Cardinals were hardly bothered by Tennessee Tech's spread attack, ruining Golden Eagles quarterback Lee Sweeney's return to Louisville. Sweeney spent a year with the Cardinals in 2005 before transferring, but his chances at leading the Golden Eagles to an upset ended early. Sweeney completed 14-of-25 for 93 yards and an interception before giving way to Josh Lowery in the third quarter.
Louisville held the Golden Eagles to 176 yards, including just 33 on the ground.
Though the Cardinals hardly needed the help, the Golden Eagles gift-wrapped two touchdowns thanks to a pair of mental miscues by running back Henry Sailes.
Trailing 27-0 in the second quarter, Sailes took a short pass from Sweeney and tried to cut up field. Finding his path filled with Cardinals, he pitched the ball behind him to no one in particular. Louisville defensive tackle Adrian Grady picked it up and rumbled 19 yards for a score to make it 34-0.
Things didn't get any better for Sailes in the second half. He was blocking during a Louisville punt when the ball bounced at the Tennessee Tech 1-yardline and scooted back up field, glancing off Sailes before rolling into the end zone. Louisville's Brandon Heath fell on the ball for a score that made it 51-3.