Kenneth Zenon led the Panthers on the ground, rushing for 70 yards on just one carry. Jerome Tarver and Michael Jason ran for 66 yards apiece and each scored a touchdown as Prairie View rolled up 266 yards rushing to 97 for the Steers.
Spivey went 11-of-19 passing with no interceptions. Shaun Stephens caught three passes for 73 yards and a touchdown for Prairie View (2-0).
Fred Dixon led the Steers (0-2) with 79 yards on 20 carries.
Prairie View outgained Texas College 451-111 yards, including just 14 yards through the air for the Steers.
The Panthers led 19-0 at the half.