Ball State (3-0, 1-0 Mid-American Conference) piled up 491 yards of offense.
Chris Jacquemain hit on 21-of-44 passes for 269 yards and a 13-yard scoring pass to Andre Jones, but was also picked off four times -- three of them by Sean Baker. Akron (1-2, 0-1) also lost a fumble.
With the score tied at 10 early in the second quarter, the Cardinals ran off the next 21 points on Lewis' two touchdown runs sandwiched around Baker's 33-yard return of a fumble.
Ball State's Ian McGarvey added field goals of 31 and 32 yards.
Deryn Bowser had eight catches for 117 yards for the Zips.
Alabama coach Nick Saban took exception with the media's outlook on his team prior to Saturday's win at Georgia, lashing out at those who "buried" the Crimson Tide.
Despite a 1-4 start to the season and a 7-11 record since taking over at Texas, coach Charlie Strong has ongoing support from school officials and key boosters, according to several sources.
Auburn senior receiver D'haquille Williams has been dismissed from the team.
Questions are being raised about the transparency of the daily fantasy industry after a DraftKings employee won $350,000 in a weekend contest on FanDuel.
As much confidence as LSU coach Les Miles expresses in the abilities of his receivers, he has apparently decided to see if the threat of lost playing time sharpens their focus.
Michael Brewer, originally expected to miss eight to 10 weeks, broke his left collarbone in the Hokies' season-opening loss to No. 1 Ohio State.