The Gamecocks (6-3, 4-2 Ohio Valley Conference) jumped out to a 14-0 lead in the first quarter on Perrilloux's 14-yard touchdown and his 9-yard passing score to James Wilkinson, who finihsed with eight catches for 123 yards.
Perrilloux, who completed 19 of 29 passes for 271 yards and an interception, later connected with Eric Johns on a 4-yard touchdown to give Jacksonville State a 21-3 lead in the second. Perrilloux also rushed for 50 yards on 10 attempts.
Terrance Holt scored on a 61-yard run and Jeff Lyle followed with a 2-yard touchdown catch from Trent Caffee for in the second the Governors (1-8, 1-5) to cut the lead to 21-16, but never drew closer.
Lyle, who had four receptions for 53 yards, caught another 2-yard touchdown pass from Caffee in the third. Ryan White led Austin Peay with 116 yards rushing on 25 carries, while Caffee threw for 145 yards.
Linebacker Myles Jack, who suffered a season-ending knee injury, said Thursday he decided to leave UCLA and enter the 2016 NFL draft because he wants to be compensated for his skills.
The tougher tests await down the road for No. 3 Baylor Bears, but coach Art Briles has seen enough of his Bears to know this is his best team.
A decision has been made that Randy Edsall will not be the football coach at Maryland next season, and discussions are taking place about how and when to separate, a source said Thursday night.
Florida State running back Mario Pender has been released from the hospital but could be given a medical redshirt if he cannot return to the field this season.
Tennessee chancellor Jimmy G. Cheek has issued a statement amid rumors that alleges coach Butch Jones fought and punched senior offensive lineman Mack Crowder during a fall practice session.
With the addition of a few tweaks, UConn football coach Bob Diaco is still planning to bring a rivalry trophy with him to Florida on Saturday when the Huskies play UCF.