Walter Peoples had a career-high 154 yards receiving on eight catches for Southeast Missouri (3-6, 1-4) and Timmy Holloman rushed for 107 yards and a touchdown. Redhawks quarterback Houston Lillard completed just 10 of 17 passes for 177 yard and threw four interceptions.
Eastern Kentucky scored in the first five minutes of the game on Walker's 37-yard touchdown run, the longest rushing play of the season for the Colonels.
Southeast Missouri answered with 16 straights points. Doug Spada made field goals of 47, 33, and 24 yards, and Holloman rushed for a 9-yard touchdown to put the Redhawks ahead 16-7.
But Eastern Kentucky dominated the rest of the game. Holland threw touchdown passes to Sizemore (14 yards) and Cody Watts (22 yards), and Jeremy Caldwell scored on a 66-yard interception return and the Colonels scored a two-point conversion.