Alexander Robinson added 83 yards rushing and a touchdown for the Cyclones (1-0), who snapped a 10-game losing streak.
North Dakota State (0-1) got as close as 24-17 midway through the third quarter before Iowa State pulled away.
Grant Mahoney hit a career-long 50-yard field goal and Arnaud found Hamilton for a 42-yard touchdown pass with 9:58 left to make it 34-17.
Pat Paschall rushed for a career-high 146 yards and a touchdown for North Dakota State, an FCS program that fell to 3-3 against FBS opponents since 2006.
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It's Rivalry Week, when College Football Playoff hopes, title aspirations and Heisman ambitions will rise and fall. Here are the four players most likely to be front and center.
Kyle Davis, the top-ranked receiver in the country for the 2016 class, has committed to Auburn, choosing the Tigers over in-state Georgia and Tennessee.
Rece Davis and Kirk Herbstreit agree that if Florida beats Alabama in the SEC Championship Game, they won't be a lock to make the College Football Playoff.
While Trevone Boykin and Josh Doctson get most of the praise, running back Aaron Green will be equally as difficult to replace for TCU next season.
Navy's shot at being the Group of 5 representative in the New Year's Six hinges on beating Houston and then winning the AAC title game.
With both teams highly ranked again, the Florida vs. Florida State rivalry is back in the spotlight. And that is a good thing for college football.
|North Dakota State||7-1||9-2|
|South Dakota State||5-3||8-3|