The Wildcats (9-1, 6-1 Colonial Athletic Association) scored touchdowns on their first five drives en route to their fourth straight victory. Aaron Ball ran for two touchdowns as Villanova rolled up 430 yards of total offense.
Towson (2-8, 1-6) lost its fifth straight game.
Whitney, who was 6 of 7 for 93 yards, left midway through the second quarter. Ball put Villanova up 35-0 on a 4-yard run and backup quarterback Antwon Young added an 82-yard TD scamper for a 42-0 third-quarter lead.
Tremayne Dameron rushed for Towson's touchdown.