In their season opener, the Buccaneers trailed 9-0 after North Greenville's Isaiah Johnson returned a punt 73 yards for a touchdown with 6:17 left in the first quarter. Charleston Southern answered with 20 straight points, capped by Moon's 2-yard rushing score.
The Crusaders (0-2) closed the gap to 20-17 when Idris Anderson scored on a 46-yard run. But Charleston Southern pulled away as Toscano threw three touchdown passes, his last coming on a 33-yarder to Kwame Krakue, to put the Buccaneers ahead 41-17 in the fourth.
Toscano, who completed 17 of 26 passes for 223 yards, also connected with Anthony Chalmers for a 32-yard touchdown in the second quarter. Moon carried 10 times for 43 yards.