Line rushed 30 times and Padron was 17 of 30 for 230 yards for the Mustangs (6-5, 5-2 Conference USA), who can clinch a spot in the conference championship game with a victory Friday against East Carolina.
Brian Anderson was 24 of 42 for 277 yards and a touchdown but also threw three interceptions for the Thundering Herd (4-7, 3-4), who fell to 0-7 all-time in Texas.
Padron threw both his TD passes in the first half, including a 41-yarder to Aldrick Robinson, to help SMU to a 24-0 halftime lead.
Marshall was held to 50 rushing yards and had its three-game losing streak snapped.
Just when you think some sanity is coming back with LSU's decision to keep Les Miles, Georgia fires Mark Richt.
Coaching staffs are bracing for a frenzy of activity on the recruiting trail thanks to all the turnover at the top.
After each week of the season, Mark Schlabach and Brett McMurphy detail the bowl matchups and the College Football Playoff.
The Playoff Predictor sees eight teams still alive for the playoff. Which teams have the most to win or lose?
Feleipe' Franks, the No. 4 pocket passer in the ESPN 300 and No. 59 player overall, committed to Florida after breaking his verbal pledge to LSU amid the Tigers' coaching uncertainty.
After finishing 97th in the FBS in scoring and 75th in passing yardage, Minnesota has fired offensive coordinator Matt Limegrover and passing game coordinator Jim Zebrowski, the school announced.