Caprio, William & Mary's third different starting quarterback this season, finished with 220 yards on 18-of-28 passing. His first touchdown pass, a 22-yarder to McBride, gave the Tribe (2-4) a 24-7 halftime lead.
Penn cut the deficit to 24-14 but Caprio's second touchdown pass, this time a 5-yarder to Sean Ballard, extended William & Mary's lead to 31-14 with 7:24 left in the third quarter.
McBride, who also hauled in seven passes in the Tribe's Sept. 22 matchup with Delaware, finished with 128 yards and has registered at least one reception of 20 yards or longer in the last six games.
Billy Ragone led Penn (1-3) with 207 yards and two touchdowns on 21-of-35 passing but was sacked four times.
An in-depth look at the recruiting class of the Auburn Tigers, who filled their biggest needs with some top-level talent.
Chris Harris Jr. and Aqib Talib did the Jayhawks proud on Sunday, helping a dominant Broncos defense to a win in Super Bowl 50.
With four straight bowl appearances, a spot in the 2013 ACC title game and a top 30 recruiting class, it is clear Duke football is not going anywhere.
Iowa has a star at cornerback in Desmond King, but he is a rising senior and the Hawkeyes have tried to restock at his position.
Five of the Big 12's quarterback recruits are current or former ESPN 300 recruits, and Oklahoma in particular added some strength at the position.
After losing a bet on the outcome of the Super Bowl, former Trojans linebacker Su'a Cravens will have some unfortunate decoration in his room.
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