TUCSON, Ariz. (AP) -- Willie Tuitama threw for five touchdowns and freshman Nicolas Grigsby rushed for 186 yards in his second Arizona start, leading the Wildcats to a 48-20 victory over Washington State on Saturday night.
Grigsby carried 30 times and caught nine passes for 76 yards, including a 22-yarder for a touchdown.
Tuitama, increasingly comfortable in first-year coordinator Sonny Dykes' spread offense, completed 22-of-31 for 346 yards with no interceptions. He also had a one-yard sneak for a score as Arizona (2-3, 1-1 Pac-10) scored 28 straight points after Washington State rallied to tie it at 20 early in the second half.
Another freshman, 6-foot-6, 250-pound tight end Rob Gronkowski, had four receptions for 115 yards, including touchdown plays of 18 and 57 yards.
The wide-open game featured 985 yards of offense, 567 for Arizona.
Down 20-7 with 2:53 left in the first half, the Cougars had 80-yard touchdown drives on their final possession of the second quarter and first possession of the third to tie it at 20. WSU would have had the lead had it not been for the first missed PAT by Romeen Abdullomahammadi in 27 attempts as Washington State's kicker.
Arizona went back on top with two third-quarter touchdowns. Tuitama threw 27 yards to Mike Thomas for one score. His 64-yard pass to Terrell Turner, the Wildcats' longest play from scrimmage this year, set up the quarterback's one-yard sneak that made it 34-20.
Gronkowski's long scoring play came next. Tuitama hit him over the middle, and the big tight end spun away from a would-be tackler, then rambled to the end zone, nearly losing his balance along the way.
The Cougars briefly went ahead 7-3 lead on Brink's 16-yard touchdown pass to Charles Dillon in the first quarter.
The Wildcats took the lead for good on their next possession, Tuitama floating a pass over Grigsby's shoulder on a 22-yard scoring play with 1:37 left in the third.
Arizona padded the lead after Devin Ross intercepted Brink's pass. Grigsby's 18-yard run set up Tuitama's 18-yard scoring pass to Gronkowski, and the Wildcats led 17-7 with 9:47 remaining in the half.
Arizona coach Mike Stoops was on the sidelines after spending several hours in a hospital Friday for treatment of kidney stones.
Arizona linebacker Scooby Wright's left knee injury is not season-ending, according to an MRI Wright had after Thursday night's opening win over UTSA, sources told ESPN's Brett McMurphy.
Syracuse starting quarterback Terrel Hunt has a significant injury to his right Achilles, head coach Scott Shafer said after the Orange's season-opening 47-0 rout of Rhode Island.
The Mountain West told ESPN's Brett McMurphy that officials correctly ruled the final play that kept Colorado from getting a potential game-tying touchdown against Hawaii before time expired.
ESPN 300 running back Elijah Holyfield, the son of former heavyweight boxing champion Evander Holyfield, has decided to stay home and attend Georgia, he announced Friday.
Miami reserve linebacker Al-Quadin Muhammad has been suspended for the season opener against Bethune-Cookman on Saturday for a violation of team rules, a source confirmed to ESPN.com
Ohio State quarterback Cardale Jones is "doing fine" after he was released from the hospital Wednesday night after being treated for symptoms related to a migraine headache.