Blow's first quarter run put the Redbirds (4-4, 2-2 MAC) on the board after Youngstown State (5-3, 1-2) grabbed a 10-0 lead. Horton's touchdown at the end of the half made it 20-13 and put Illinois State in front to stay.
Luke Drone completed 19 of 30 for 278 yards for Illinois State. Blow ran for 128 yards on 17 carries and Horton gained 119 yards on five catches.
The Penguins' Kevin Smith rushed for 70 yards on 19 carries and scored on a 1-yard run with 10:10 to play to finish the game's scoring. Youngstown State's Ferlando Williams added 59 yards on eight tries and five receptions for 71 yards.
South Carolina football players will wear stickers on their helmets this season to honor the nine people who died in a shooting at Emanuel AME Church in Charleston this past June.
Washington has found its starting quarterback, but coach Chris Petersen said the Huskies will keep that information under wraps until Friday's season opener at No. 23 Boise State.
Joey Counts scored on a 1-yard run on fourth-and-goal with 2 seconds left to give Montana a 38-35 victory over four-time defending FCS champion North Dakota State on Saturday.
Transfer Vernon Adams will be the starting quarterback when Oregon begins its season against Eastern Washington on Sept. 5.
Tim Beckman is threatening legal action after Illinois fired him as football coach Friday amid allegations of influencing medical decisions and pressuring players to play hurt.
LSU offensive coordinator Cam Cameron revealed in a post-practice news conference that he has been treated for prostate cancer but plans to coach this season.