HOUSTON (AP) -- Case Keenum threw five touchdown passes to lead Houston to a 55-3 win over Southern on Saturday night, giving Kevin Sumlin a victory in his first game as the Cougars' coach.
Hafner and Castile were the leading receivers for the Cougars (1-0) with 103 and 83 yards, respectively.
Andre Kohn scored the first points of the game with a one-yard touchdown in the first quarter. Ben Bell added a 20-yard field goal early in the second quarter.
The Cougars added a pair of touchdowns in the next five minutes. Castile caught a 30-yard touchdown from Keenum, followed about two minutes later by Hafner's 36-yard TD.
The Jaguars (0-1) got on the board when Josh Duran made a 36-yard field goal to make it 24-3.
But the Cougars answered with two more scores just before halftime. Keenum hit Castile for a 22-yard touchdown. Patrick Edwards then made the first touchdown catch of his career to make it 38-3.
The Cougars broke a 53-year school record, scoring the most points in team history for a new head coach. Bill Meek's Cougars scored 54 points in a 42-point win over Montana in 1955.
Will Grier threw four touchdown passes to four receivers -- all in the first half -- and No. 25 Florida downed third-ranked Mississippi 38-10 on Saturday night.
Leonard Fournette highlighted his SEC-record third straight 200-yard game with a 75-yard touchdown run, and No. 9 LSU overcame Eastern Michigan 44-22 on Saturday night.
An officiating error led to an Oklahoma State touchdown Saturday in the Cowboys' 36-34 win over Kansas State.
Texas A&M receiver Ricky Seals-Jones, who was ejected for targeting midway in the second quarter of Saturday's game, took to Twitter late in the game, retweeting a tweet that questioned the call.
Florida State running back Dalvin Cook exited in the first quarter of the Seminoles' 24-16 win over Wake Forest with a left hamstring injury. He is day-to-day.
As if things weren't going bad enough at Texas, the Longhorns appear to have players on Twitter during lopsided losses and jabs at their coach accidentally being sent from other nearby teams.