LOUISVILLE, Ky. (AP) -- Jazz Covington had 21 points and 10 rebounds to lead Louisville to a 61-51 upset of Notre Dame (No. 19 ESPN/USA Today, No. 20 AP) on Saturday.
Angel McCoughtry added 10 points and 14 rebounds for the Cardinals (12-3 overall, 3-1 Big East), who handed the Irish (10-5, 1-3) their fourth loss in five games.
Charel Allen had 10 points for Notre Dame, which shot 32 percent from the field. Megan Duffy scored just eight points on 2-of-10 shooting, eight below her team-leading average.
Louisville took control with a 15-0 run midway through the first half, holding Notre Dame scoreless for almost 10 minutes.
Louisville held the Irish to just 21 percent shooting in the half while building a 30-15 lead.
The Cardinals outrebounded the Irish 55-29 and overcame 22 turnovers to win their first game over a Top 25 opponent in nearly two years. They hadn't beaten a Top-25 team since knocking off then-No. 23 Houston on Jan. 25, 2004.
The loss leaves Notre Dame in danger of dropping out of the Top 25 after spending 28 consecutive weeks in the polls.