CINCINNATI -- Louisville stuck to its defensive game plan, which focused on limiting No. 23 Xavier's standout center Ta'Shia Phillips.
The No. 9 Cardinals ran it to perfection, holding Phillips to five points in the 65-55 win on Saturday.
Candyce Bingham scored 23 points and had 10 rebounds, while Angel McCoughtry added 16 points and 11 boards for the Cardinals (3-0).
Xavier's Tudy Reed led all scorers with 31 points, including six 3-pointers in the first half.
Phillips had just one point and five rebounds in the opening half, going without a field goal until 16:39 left in the second. She finished 1-of-4 from the field
"We told our kids that somebody else was going to be Atlantic-10 Player of the Week," said Louisville coach Jeff Walz. "Phillips is such a dominant player, I'll take my chances with other kids having to step up."
Phillips, who had 23 points and a school-record 25 rebounds Wednesday in a loss to No. 4 North Carolina, finished with eight rebounds.
A frustrated Phillips committed her second foul with 9:30 remaining in the first half.
"Every time the ball got into her, we would double-team her, and making sure our weak-side was there for any back-cuts," Bingham said. "We practiced that all week. Coach said to stick with the game plan."
Reed kept Xavier (2-2) close with her long-range shooting. Her fifth 3-pointer highlighted an 8-0 run, helping the Musketeers lead 28-24 at halftime.
"We were fortunate to just be down four," Walz said. "If it's a 15-point game, we probably are going have to change our strategy. We stuck with it."
Bingham hit three consecutive 3-pointers to put the Cardinals ahead 46-36 with 9:21 left.
Reed's put back made it 55-51 with less than three minutes left. But the Cardinals hit their free throws down the stretch, finishing 17-of-22 overall.
Reed was the only player in double figures for Xavier. Special Jennings was the next high scorer with six points.
"They really crowded in [on Phillips]," said Xavier coach Kevin McGuff. "But we did not do a good job getting balance in our offense."