Rodriguez hit a solo shot in the sixth inning of a 10-8 loss to the Boston Red Sox off starter Josh Beckett and a two-run drive in the seventh against reliever Scott Atchison. The first homer followed Mark Teixeira's solo shot, and the second one trimmed New York's deficit to 10-7.
It was A-Rod's 58th career multihomer game and fourth this season. His previous one was last Friday at Baltimore.
Next up on the home run list for Rodriguez is former teammate Ken Griffey Jr., who retired this season with 630.