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49ers 45, Bills 3

Updated: October 7, 2012, 9:12 PM ET
Associated Press

SAN FRANCISCO -- Joe Montana never did it. Neither did Steve Young or Y.A. Tittle. Even the architect of the West Coast offense, Bill Walsh, could only imagine such a massive mark.

Of all the Hall of Fame quarterbacks and coaches in the history of the San Francisco 49ers, leave it to Alex Smith and Jim Harbaugh to set a new standard.

Smith threw for a season-high 303 yards and three touchdowns, Frank Gore ran for 106 yards and a score, and the 49ers amassed a franchise-record 621 ...

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