Parker is listed as questionable; Steelers players who practice on the Friday before games usually play.
Parker, a three-time 1,000-yard rusher, recently missed five games in a six-game span with knee and shoulder injuries. He played in the last two games, but was pulled when the knee flared up after he gained 37 yards on 14 carries against Cincinnati on Nov. 20.
The Steelers were hopeful that the two veteran cornerbacks would return against the Patriots (7-4) and Matt Cassel, who has thrown for 400-plus yards in his last two games. Pittsburgh (8-3) leads Baltimore (7-4) by one game in the AFC North.