With starting defensive tackle Fred Robbins battling a shoulder injury, the defending Super Bowl champions signed defensive tackle Jeremy Clark off their practice squad.
Knight, a 12-year veteran who was signed by the Giants in March, was placed on injured reserve Saturday. He has been bothered by a hip condition all season and was inactive last week at Arizona, marking the second time he did not suit up this year.
When Knight was inactive at Cleveland on Oct. 13, it ended his streak of 160 consecutive games.
Knight played in nine games and was credited with 13 tackles and four special teams tackles. He played for New Orleans, Miami, Kansas City and Jacksonville before joining the Giants.
Clark signed as a free agent July 27. He was waived Aug. 30 and signed to the practice squad the following day. The University of Alabama product spent the 2007 season on the Philadelphia Eagles' practice squad.