The game was moved from 1 p.m. to 8:15 p.m. ET under the NFL's flex scheduling policy.
The Giants (11-2) have clinched the NFC East and lead the NFC South-leading Panthers (10-3) by a game. The winner would have the edge if they finish tied for the top seed by virtue of a head-to-head victory.
San Diego at Tampa Bay, scheduled to be the Sunday night game, will be played at 1 p.m. ET and televised by CBS.
Philadelphia at Washington and Atlanta at Minnesota on Dec. 21 will move from 1 p.m. to 4:15 p.m. ET and be televised on FOX affiliates.