Cleveland coach Eric Mangini tried to keep his decision a secret but it turned out to be one of the worst-kept secrets in sports this week.
Quinn began creating separation in the third preseason game and neither quarterback has played in a game situation since, making the call predictable. Mangini did not notify Quinn or Derek Anderson about the decision until Tuesday.
This will be Quinn's fourth career start and first to open the season for the Browns. The former first-round pick is Cleveland's third Week 1 starting quarterback in the past three years. Anderson and Charlie Frye were the other two.
Quinn went 1-2 last season before a finger injury that required surgery.
The Browns will also start rookie Alex Mack at center.
Vikings wide receiver Bernard Berrian, who did not play most of the preseason because of a hamstring injury, was active for the opener. Berrian led the NFL last season with 20.1 yards per catch and scored a career-high seven touchdowns.
James Walker covers the AFC North for ESPN.com. The Associated Press contributed to this story.